As a member of the National Resistance, Konstantinos launched major political initiatives towards the understanding of the resistance organizations, the National Organization of Crete (NOC) and the -under Communist control- National Liberation Front (NLF), in order to avoid the civil war. Something that was finally reached only in Crete.

To this end, on November 7, 1943 an agreement was signed, in Therissos, between the resistance organizations NOC and NLF which was negotiated and signed by Konstantinos Mitsotakis, on behalf of NOC and Miltiades Porphyrogenis on behalf of NLF. It's worth noticing that, the agreement text was written by the same Konstantinos Mitsotakis. The Therissos Agreement, apart from the establishment of a mutual understanding and cooperation climate between these resistance groups and the avoidance of civil war in Crete, also contributed to joint policy initiatives such as joint proclamation to the Cretan people, issued by NOC and the NLF, in January 1944, and the signing of a new cooperation agreement on April 2, 1944, during the works of the First Pan-Cretan Congress. This agreement, supplemented with the Tromarissa agreement, signed on September 15, 1944, at NLF headquarters and contributed fully to the ousting of the ideological confrontation between the two resistance groups and the consolidation of a climate of mutual respect and cooperation.

On November 22, 1945, the British Colonel Dolby, of Unit 133 via the Middle East headquarters, suggested the decoration of Konstantinos Mitsotakis by the British Authorities for outstanding services and his awarding with the Bravery Medal. The same proposal was also suggested by the Greek Authorities.